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ivermectin dosage for humans can be administered intravenously, topically, or orally.

The systemic circulation absorbs oral doses; alcoholic solutions are more readily absorbed orally than tablets and capsules.

The body has a large distribution of ivermectin.

The presence of P-glycoprotein (whose function is impacted by mutations in the MDR1 gene) prevents ivermectin from easily passing through the blood-brain barrier in mammals.

If substantial dosages of ivermectin are used, crossing may still become significant, with brain levels peaking 2–5 hours after delivery.

Unlike in mammals, ivermectin can penetrate the tortoise´s blood-brain barrier, frequently leading to death.

Human CYP3A4 breaks down ivermectin into eight distinct compounds, two of which (M1, M2) are still harmful to mosquitoes.

Additionally, M1 and M2 have longer elimination half-lives—roughly 55 hours.

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